Mone Zaidi graduated in medicine from King George’s Medical College, India, and trained clinically at the Hammersmith Hospital, London, under the tutelage of Professor Iain MacIntyre, FRS, who discovered calcitonin. After obtaining a PhD and MD from the University of London, Dr. Zaidi held faculty appointments for over 8 years, before he was recruited to Mount Sinai School of Medicine as Professor of Medicine and Founding Director of The Mount Sinai Bone Program. He is currently the Mount Sinai Professor of Clinical Medicine and Director of the Center for Translational Medicine and Pharmacology.

Zaidi has made groundbreaking discoveries on mechanisms of skeletal homeostasis in health and disease. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone cells. In 2003, Zaidi’s group published the first evidence for a pituitary–bone axis, a breakthrough in physiology in which pituitary hormones could affect the skeleton directly. In two recent groundbreaking papers in Nature, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and prevented neurodegeneration—in essence, laying a firm foundation for a single anti-FSH agent to treat osteoporosis, obesity and Alzheimer’s disease. This corpus of work was selected by Nature Medicine as one of eight “Notable Advances” in biomedicine for 2017 and was editorialized in the New York Times. Constituting a total of over 480 publications in journals and books, including Cell, Nature and PNAS, Zaidi’s research has been funded continuously by the NIH.

He was elected to the American Society of Clinical Investigation (2000), Association of American Physicians (2004), Interurban Clinical Club of which he is President (2004), the  Practitioners’ Society (the oldest medical society in the U.S.) (2016) and the Association of Professors of Medicine (2014). Zaidi was made Master of the American College of Physicians, received the Harrington Scholar–Innovator Award, elected as Fellow of the American Association of Advancement of Science (AAAS), and of the National Academy of Inventors, won the Austrian International Research Prize and the Special Recognition Award from the Association of Professors of Medicine, was bestowed upon with an Honorary Fellowship by the British Pharmacological Society, and is recipient of five honorary doctorates. He was the 2023 Commencement Speaker at the University of Connecticut, and was elected as a Foreign Member of Academia Europaea.